Designing a topological algorithm for 3D activity recognition

Voxel carving is a non-invasive and low-cost technique that is used for the reconstruction of a 3D volume from images captured from a set of cameras placed around the object of interest. In this paper we propose a method to topologically analyze a video sequence of 3D reconstructions representing a tennis player performing different forehand and backhand strokes with the aim of providing an approach that could be useful in other sport activities

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Designing a topological algorithm for 3D activity recognition

Voxel carving is a non-invasive and low-cost technique that is used for the reconstruction of a 3D volume from images captured from a set of cameras placed around the object of interest. In this paper we propose a method to topologically analyze a video sequence of 3D reconstructions representing a tennis player performing different forehand and backhand strokes with the aim of providing an approach that could be useful in other sport activities

An Evening with the China Division

The transcript of this meeting was published in the Review and Herald, June 20, 1946, page 235. Duration: 1:58:15 The recording begins a few minutes into the program. (0:0) J. L. McElhany reads a letter from President Truman regretting that he is unable to address the SDA General Conference. (1:25) W. P. Bradley introduces special music (1:59) Mrs. Minnie Iverson Wood sings, accompanied by violin (George Wargo) and piano (unknown) (7:54) Minnie Iverson Wood’s second song (12:43) W. P. Bradley introduces E. L. Longway, acting president of the China Division (13:57) E. L. Longway reports on the China Division and introduces Abbie Dunn (21:07) Abbie Dunn speaks about her time in China (26:27) E. L. Longway stops Dunn because of time. He honors several workers. He introduces C. H. Davis. (28:46) C. H. Davis speaks (39:05) E. L. Longway introduces S. J. Lee, treasurer of the Shanghai Committee (40:18) S. J. Lee talks about traveling between Shanghai and Chungking (54:28) E. L. Longway introduces Mrs. Hartwell and family (55:27) Mrs. Raymond Hartwell plays “Holy City” on the marimba (1:01:46) E. L. Longway introduces E. H. James (1:02:41) E. H. James speaks (1:11:26) Milton Lee introduces David Lin (1:12:19) David Lin plays a Voice of Prophecy broadcast in Chinese (1:17:38) E. L. Longway introduces Mrs. John Oss (1:19:37) Mrs. John Oss discusses her experience being interned in Shanghai (1:29:17) E. L. Longway honors more interned workers and introduces G. J. Appel and Harold Shultz in Mongolian and Tibetan garb. (1:30:22) G. J. Appel and Harold Shultz speak about the work in Tibet and Mongolia (1:36:18) E. L. Longway introduces Dr. Herbert Liu (1:36:46) Dr. Herbert Liu discusses medical work in Chungking, China (1:43:23) E. L. Longway introduces Jerry Christensen (1:44:10) Jerry Christensen speaks (1:52:10) E. L. Longway introduces Y. H. Chu, editor of the Chinese Signs of the Times (1:52:27) Y. H. Chu speak

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine a-hydroxylating monooxygenase (PHM)

Peptidyl a-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of a-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for the management of insect pests. We show here that relatively simple ground state analogs of the PHM substrate hippuric acid (C6H5-CO-NH-CH2-COOH) inhibit the enzyme with Ki values as low as 0.5 µM. Substitution of sulfur atom(s) into the hippuric acid analog increases the affinity of PHM for the inhibitor. Replacement of the acetylglycine moiety, -CO-NH-CH2-COOH with an S-(thioacetyl)thioglycolic acid moiety, -CS-S-CH2-COOH, yields compounds with the highest PHM affinity. Both S-(2-phenylthioacetyl)thioglycolate and S-(4-ethylthiobenzoyl)thioglycolic acid inhibit the proliferation of cultured human prostate cancer cells at concentrations >100-fold excess of their respective Ki values. Comparison of Ki values between mammalian PHM and insect PHM shows differences in potency suggesting that a PHM-based insecticide with limited human toxicity can be developed. © 2008 Elsevier Ltd. All rights reserved